I followed this official blog post "Buffer protocol support" and came up with a short example of simple video player in panda3d using numpy 2d array as texture. The trick was to use setRamImage on Texture object. To do that, we have to setup the memory layout using setup2dTexture method.

Texture format and Texture componentType need to be set correctly. By try and error, I figured that the combination of T_unsigned_byte and F_luminance works for 8 bit gray scale image.